Aber ihr wollt mir doch wohl ned weismachen das das gut ist? Ich zumindestens weiss wenn ich Connections hätte wär ich drauf , weil es ein höllenzeug ist und den Körper einfach ganz anders mitnihmt. Auch wenn man da mal "NUR" ein Wochenende im Monat abgeht..

Before I do any drugs, I do a shitton of reading on it. I go through all the medical literature because I want to know what I'm getting into. I've found that Meth has the exact same safety profile as dextro. Just another demonized drug because of idiot users. Before you call it addictive let me explain what I've found from scientific journals:

1. First off, Methamphetamine is only psychologically addictive. Just like Cannabis, food, or the internet. Methamphetamine's addiction potential is equal to prescription dextroamphetamine (at similarly potent doses). If you are wondering why d-amph addicts are so much rarer, it's because d-amph is typically given out in prescription tablets only. People can still break it down and snort it, but the difference is that these prescriptions regulate their dosage every month and drastically lowers the chances of addiction. Just another reason why the drug war is such a failure really. European speed is so diluted and cut that I'd be surprised if you even got 10% dextro in your powder. No American dealer wants to sell dextroamph because it takes an extra step in synthesis and is less potent. If Europe had the availability to meth precursors like America did, absolutely NO dealer would be selling l- or d-amphetamine. Pharmaceutical companies have the incentive to use d- and l-amphetamine because meth carries such a stigma that patients won't want to take it. Big pharma has near free access to precursors and laboratories so making the slightly less potent d-amph costs almost nothing to them. It is saddening that people who are "pro-drugs except for meth" are tricked by the same misinformation that they hate so much when it's against cannabis. Hopefully by this point, you and I are on the same page and have moved past this "evil meth" label. Thus, I will refer to meth as amphetamine from now on.

Significant withdrawal effects only occur when amph is continuously redosed in high dosages. Why? Because constant redosing causes neurotoxicity. The long half life of all amphetamine means that redosing will additively increase blood plasma levels and your brain will soak in that. Acute tolerance shuts out euphoria around the time you reach your first half life. Redosing = excitotoxicity and accumulation of oxidative reactive species in the absense of most of the euphoria. Daily usage is only safe at therapeutic dosages (UNDER ~0.5mg/kg). It seems like it is generally agreed upon that meth is more potent weight by weight than dextro (about 1.3x). When the dosages are matched, they have the exact same safety profile.

Chronic use at anything above therapeutic level causes persisting DA striatal depletion. As in, it comes back VERY slowly (think years) and it isn't 100%. You can withdraw from Heroin and get away without lasting physical damage. The same cannot be said for amphetamines. The striatal depletions go unnoticed by binge users until they stop dosing whereupon shit gets real. Quickly. These are the only people that get severe withdrawal effects and feel extremely addicted. Just like every other drug, binging is bad. Before you call therapeutic dosages too pussylike, read the rest of my post.

2. Pre-treatment. Holy fuck I was glad to find out about this before I started using. Pre-treatment takes only one week and it permanently boosts all your subsequent amphetamine effects. It is called sensitization or reverse-tolerance. When taken at sub neurotoxic dosages, the brain becomes supersensitized to all subsequent amphetamine dosages. This effect has been tested to last longer than 120 days and is probably permanent. Animals were intially given a single small amphetamine dosage. In 120 days, they received their second dosage and the effects were dramatically boosted. Tests in human subjects show that the subjective high is nearly doubled from baseline. More research has shown that the optimal pre-treatment schedule is 0.15mg/kg daily for 7 days. The longer the withdrawal period after that, the stronger the effects (up to 30 days when it levels out). Also, did I mention that pre-treatment significantly reduces neurotoxicity in subsequent binges and high dosages? If your first few amphetamine uses were high dosage, you shocked your brain. You most likely had neurotoxic hyperthermia which diminishes sensitization.

Source of pretreatment on sensitization and reverse tolerance:  http://deepblue.lib.umich.edu/bitstream/2027.42/26144/1/0000221.pdf
Source of pretreatment on neurotoxicity: www.nature.com/?file=/npp/journal/v28/n10/abs/1300247a.html
Bonus source for one dosage causing lasting sensitization: www.neuro.cjb.net/content/19/21/9579.short
(please keep in mind these dosages in the article are for rats and NOT for humans)

3. Any tolerance to amphetamines that last longer than 5 days is caused by neurotoxicity. The main reason for amphetamine's tolerance is its half life and how quickly the body adjusts to the presence of amphetamine in the blood. After only 3 days (approximately 5 half lives, i.e. ~97% of the drug is gone), this tolerance should be almost completely gone. Any persisting tolerance after 5 days was caused by striatal DA depletions as well as downregulation of D2 receptors. Again, if your tolerance lasts more than 5 days, reconsider your amount and frequency of dosage. Repeated high dosages without adequate time in between will fuck up your shit. The rewarding effects of sensitization is also severely diminished by this binge use.

Source: www.sciencedirect.com/science/article/pii/S0278584602002579
(I've seen several other sources but this is one I found with a quick search)

4. If you enjoy higher dosages, you must spread them out. This goes back to my last point. Moderately high dosages can actually be safe given that you washout the drugs (about 5 half lives) before redosing.

5. If you are female, the effects of amphetamine neurotoxicity are two folds stronger and psychosis along with addiction potential occur at half the dosage for males. The presence of certain male androgens are neuroprotective against amphetamine. Sorry, women.

6. Smoking and IV have the same safety profile as other ROA's when dosages are matched for bioavailibility and may actually be safer because of their shorter half lives. Rats can take single 25mg/kg injections with no neurotoxicity because their amphetamine half life is only one hour compared to the human time of 9-12 hours. Amphetamines are one of the rare drugs where these ROAs are safer because amphetamine neurotoxicity is primarily exacerbated by the time it stays in the body. Unfortunately, binge use with smoking or IV causes half life to be irrelevant and the safety profile becomes much more dangerous.

7. If you binge, STAY out places that are hotter than room temperature! Heat literally multiplies the tolerance and deficits you are causing to your brain. And, you must have already caused a lot of deficits if you are dumb enough to be a binge user.

To sum it up, DON'T FUCKING BINGE!

8. If you have suffered psychosis from amphetamine, I would consider stopping usage. Forever. And yes, even if it only happened once. The implications from psychosis are more than just some temporary effect because you didn't sleep. Amphetamine psychosis is actually caused by the repeated dosage - sleep deprivation only made your brain more vulnerable. The variables that play into psychosis are so wide that studies have yet to really be conclusive on them. Currently, it is believed that prolonged amphetamine blood plasma induces dopamine hyperreactivity. Guess how schizophrenics are diagnosed? Dopamine hyperactivity. Again, this probably causes lasting deficits.

Want to avoid psychosis? Don't. Binge. It is nearly impossible to induce psychosis if there are more than 5 hours of sleep between dosages unless you were already genetically predisposed.

Here's the schedule a beginner should follow for daily productive use and to prevent neurotoxicity (Assuming 99% bioavailability. Adjust dosages for your ROA bioavailability):

Days 1-7: 0.15mg/kg
Days 8-?: <0.5mg/kg for males, <0.25mg/kg for females
No more than once a day

For recreational use:

Days 1-7:0.15mg/kg
Days 8-?: <1.0mg/kg for males, <0.5mg/kg for females
No more than once every 3-4 days

After pretreatment and sensitization, 1.0mg/kg WILL bring a satisfying rush. On a 160 pound person, that would be about 72mg. If it sounds too little to you, than you have gone too far.

It's that simple. Moderation is key, what a surprise huh? If everybody took amphetamines responsibly with milligram scales, we would probably be exploring the universe by now.

P.S. As a bonus, take Vitamin C and E for antioxidants. Take Magnesium to slow down acute tolerance (NMDA antagonist = be higher for longer! YAY). Zinc supplementation was also found to be synergistic with amphetamine in ADHD patients. I don't know its effects on normal people, but I take it anyway. For further reading, look up "Robinson TE". He is by far my favorite researcher. Another goodie is Carl Hart. He is a forerunner on meth research and always talks about the exaggerated claims on meth. He himself said that scientists have known for a long time that methamphetamine is exactly like dextroamphetamine at a drug policy conference. Watch him speak here:

 http:// www.youtube.com/watch?v=2wNS_aRxTqs

Part II (I'm bored and thought more should know):
-Take Nicotinamide (also known as niacinamide) pre-dosage or post-dosage. If you have niacin, it'll work as well since it is metabolized into niacinamide in the digestive system. It prevents depletion of energy (measured in ATP/ADP ratio for those that took biology) and really helps block any feeling of comedown or feeling tired afterwards. It also reduces neurotoxicity potential - always a welcome effect. Niacinamide is directly converted into NADH (available energy for the body) which is important for the brain before being subjected to amphetamine or for recuperating afterwards. Oddly enough, ingestion of niacinamide at the same time as amphetamine had no change. Studies have shown it effective only in pre and post dosage scenarios (3 hours before or 6 hours after)/

Source on energy depletion (d-amph): www.ncbi.nlm.nih.gov/pubmed/10566977
Source on energy depletion 2 (meth):  http://journals.lww.com/neuroreport/Abstract/1997/05260/Nicotinamide_attenuates_methamphetamine_induced.18.aspx
Anecdotal sources: www.addforums.com/forums/showthread.php?t=65179
Anecdotal source 2: Me.

- Avoid mixing caffeine with any amphetamines. I posted this in another thread, but caffeine antagonizes adenosine receptors which are involved in amphetamine's mechanism of action. This directly slows down the removal of amphetamine from the blood. At first, this may sound cool, but if you remember from what I said earlier, the brain shuts out the euphoria long before you even reach the first half-life (about 10 hours). Once again, the longer amphetamine stays in the blood, the harder neurotoxicity hits. This is why you should stay away from cut stuff because the dealer is trading your safety in exchange for extra money in his pocket. Amphetamines are great for narcolepsy because no matter how often you take them, significant tolerance does not develop to its wakefulness effects. You do not need caffeine along with it unless you enjoy insomnia. Admittedly, binge users may want insomnia to keep dosing but I'll just pretend like these people don't exist.

-Cannabis in conjuction with amphetamine is probably helpful. I say probably because there has been only one study done on this comparing the performance of 3 different groups - non-drug users, methamphetamine-only users, and methamphetamine + cannabis users. From the data, if I said non-users were at 100%, meth+cannabis would be 95% and meth-only users would be at 70%. Meth+cannabis users actually beat the non-users in several tests. There are too many factors that weren't accounted for (i.e. if cannabis merely reduced their meth usage) for me to say outright that weed helps with amphetamine neurotoxicity, but it sure looks like it. What it DOES show is that cannabis does not add physical damage when used with amphetamine. So toke away! Also, if it was a concern to anyone reading, this study involved patients from an addiction clinic. Meaning high dosage binge users. Responsible amphetamine users do not suffer the same impairments that they do.

Source: www.hawaii.edu/hivandaids/Neurocognitive_Performance_of_Meth_Users_Discordant_for_Hx_of_Marijuana_Exp.pdf

Ganz ehrlich wenn ich hier sowas wie von "Die Menge ist das Gift" höre kommt mir das kotzen..
Wollt ihr jetz sogar Crystal schön reden? Dann weist euch lieber gleich in die Klapse ein Mann o mann!

Crystal ist sau geil (ja i.V noch geiler!) und ja Crystal ist auch sau gefährlich, ich finde zwar wenn man gutes Crystal hatt das nicht mit allen möglichen gestreckt ist, halten sich die NW's in Grenzen und pennen an dem Tag kann ich nachm letzten Schuss wenn er so 2-5 Stunden her is auch wunderbar..

Aber ihr wollt mir doch wohl ned weismachen das das gut ist? Ich zumindestens weiss wenn ich Connections hätte wär ich drauf , weil es ein höllenzeug ist und den Körper einfach ganz anders mitnihmt. Auch wenn man da mal "NUR" ein Wochenende im Monat abgeht..

Passt vielleicht nicht ganz in den Thread, wusste allerdings nicht wo ich sonst nachfragen soll,da ich nicht extra einen Thread eröffnen wollte. Ich wollte fragen welche Dokus über Crystal empfehlenswert sind oder von mir aus über Amphetamine allgemein und nicht speziel C.

Passt vielleicht nicht ganz in den Thread, wusste allerdings nicht wo ich sonst nachfragen soll,da ich nicht extra einen Thread eröffnen wollte. Ich wollte fragen welche Dokus über Crystal empfehlenswert sind oder von mir aus über Amphetamine allgemein und nicht speziel C.