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dabei seit 2012
3.775 Forenbeiträge
1 Tripberichte
9 Galerie-Bilder

  Geschrieben: 27.12.18 12:49
Kavalactone content and chemotype of kava beverages prepared from roots and rhizomes of Isa and Mahakea varieties and extraction efficiency of kavalactones using different solvents

Abstract:

Wang et al. schrieb:
The South Pacific islanders have consumed kava beverage for thousands of years. The quality of kava and kava beverage is evaluated through determination of the content of six major kavalactones including methysticin, dihydromethysticin, kavain, dihydrokavain, yangonin and desmethoxyyangonin. In this study, we determined contents of kavalactones in and chemotype of kava beverages prepared from roots and rhizomes of Isa and Mahakea varieties and extraction efficiency of five different solvents including hexane, acetone, methanol, ethanol and ethyl acetate. The six major kavalactones were detected in all kava beverages with these five solvents. Different solvents had different extraction efficiencies for kavalactones from the lyophilized kava preparations. The contents of kavalactones in the extracts with acetone, ethanol, and methanol did not differ significantly. Ethanol had the highest extraction efficiency for the six major kavalactones whereas hexane gave the lowest extraction efficiency.

Eine angewiderte Dame mit einem Dinkelcroissant wirft einen Euro in den Hut und kommt sich deswegen nicht so sinnlos vor,
Im Grunde ein gutes Geschäft für sie, normalerweise muss sie für dieses Gefühl 18 Jahre lang ein Kind großziehen
Traumländer



dabei seit 2014
135 Forenbeiträge
2 Galerie-Bilder

  Geschrieben: 28.12.18 18:02
zuletzt geändert: 29.12.18 13:53 durch Dao (insgesamt 1 mal geändert)

»Zu einer Erkenntnis […] muß man durch Not, Leiden an seiner Fülle gekommen sein, muß geglaubt haben, ›entwurzelt‹ zu sein […], muß am Intellekt gelitten und ihn durch den Geist überwunden – muß mit dem Menschen gerungen haben.«
— Ernst Toller
Traumländer



dabei seit 2015
1.042 Forenbeiträge
5 Tripberichte
2 Galerie-Bilder

Homepage ICQ MSN Skype
  Geschrieben: 30.12.18 14:46
The protective effect of green tea catechins on ketamine-induced cystitis in a rat model
Töricht ist, wer behauptet, der psychedelische Weg sei frei von Risiko.
Kurzsichtig ist, wer glaubt, das Risiko lohne sich nicht.
Moderator



dabei seit 2012
3.775 Forenbeiträge
1 Tripberichte
9 Galerie-Bilder

  Geschrieben: 11.01.19 16:55
The emergence of new psychoactive substance (NPS) benzodiazepines: A review

Manchester et al., Drug Testing and Analysis, 2018, Vol. 10, No. 1, P. 37-53

Abstract:

Manchester et al. schrieb:
The market for new psychoactive substances has increased markedly in recent years and there is now a steady stream of compounds appearing every year. Benzodiazepines consist of only a fraction of the total number of these compounds but their use and misuse has rapidly increased. Some of these benzodiazepines have only been patented, some of them have not been previously synthesised, and the majority have never undergone clinical trials or tests. Despite their structural and chemical similarity, large differences exist between the benzodiazepines in their pharmacokinetic parameters and metabolic pathways and so they are not easily comparable. As benzodiazepines have been clinically used since the 1960s, many analytical methods exist to quantify them in a variety of biological matrices and it is expected that these methods would also be suitable for the detection of benzodiazepines that are novel psychoactive substances. Illicitly obtained benzodiazepines have been found to contain a wide range of compounds such as opiates which presents a problem since the use of them in conjunction with each other can lead to respiratory depression and death. This review collates the available information on these benzodiazepines and provides a starting point for the further investigation of their pharmacokinetics which is clearly required.

Eine angewiderte Dame mit einem Dinkelcroissant wirft einen Euro in den Hut und kommt sich deswegen nicht so sinnlos vor,
Im Grunde ein gutes Geschäft für sie, normalerweise muss sie für dieses Gefühl 18 Jahre lang ein Kind großziehen
Moderator



dabei seit 2012
3.775 Forenbeiträge
1 Tripberichte
9 Galerie-Bilder

  Geschrieben: 28.01.19 21:04
Predicting Responses to Psychedelics: A Prospective Study

Haijen et al., Frontiers in Pharmacology, 2018, 9, 897

Abstract:

Haijen et al. schrieb:
Responses to psychedelics are notoriously difficult to predict, yet significant work is currently underway to assess their therapeutic potential and the level of interest in psychedelics among the general public appears to be increasing. We aimed to collect prospective data in order to improve our ability to predict acute- and longer-term responses to psychedelics. Individuals who planned to take a psychedelic through their own initiative participated in an online survey (www.psychedelicsurvey.com). Traits and variables relating to set, setting and the acute psychedelic experience were measured at five different time points before and after the experience. Principle component and regression methods were used to analyse the data. Sample sizes for the five time points were N = 654, N = 535, N = 379, N = 315, and N = 212 respectively. Psychological well-being was increased 2 weeks after a psychedelic experience and remained at this level after 4 weeks. Higher ratings of a “mystical-type experience” had a positive effect on the change in well-being after a psychedelic experience, whereas the other acute psychedelic experience measures, i.e., “challenging experience” and “visual effects”, did not influence the change in well-being after the psychedelic experience. Having “clear intentions” for the experience was conducive to mystical-type experiences. Having a positive “set” as well as having the experience with intentions related to “recreation” were both found to decrease the likelihood of having a challenging experience. The baseline trait “absorption” and higher drug doses promoted all aspects of the acute experience, i.e., mystical-type and challenging experiences, as well as visual effects. When comparing the relative contribution of different types of variables in explaining the variance in the change in well-being, it seemed that baseline trait variables had the strongest effect on the change in well-being after a psychedelic experience. These results confirm the importance of extra-pharmacological factors in determining responses to a psychedelic. We view this study as an early step towards the development of empirical guidelines that can evolve and improve iteratively with the ultimate purpose of guiding crucial clinical decisions about whether, when, where and how to dose with a psychedelic, thus helping to mitigate risks while maximizing potential benefits in an evidence-based manner.

Eine angewiderte Dame mit einem Dinkelcroissant wirft einen Euro in den Hut und kommt sich deswegen nicht so sinnlos vor,
Im Grunde ein gutes Geschäft für sie, normalerweise muss sie für dieses Gefühl 18 Jahre lang ein Kind großziehen
Moderator



dabei seit 2012
3.775 Forenbeiträge
1 Tripberichte
9 Galerie-Bilder

  Geschrieben: 29.01.19 14:47
Increased nature relatedness and decreased authoritarian political views after psilocybin for treatment-resistant depression

Carhart-Harris et al., Journal of Psychopharmacology, 2018, Vol. 32, 7, 811–819

Abstract:

Carhart-Harris et al. schrieb:
Rationale:
Previous research suggests that classical psychedelic compounds can induce lasting changes in personality traits, attitudes and beliefs in both healthy subjects and patient populations.

Aim:
Here we sought to investigate the effects of psilocybin on nature relatedness and libertarian–authoritarian political perspective in patients with treatment-resistant depression (TRD).

Methods:
This open-label pilot study with a mixed-model design studied the effects of psilocybin on measures of nature relatedness and libertarian–authoritarian political perspective in patients with moderate to severe TRD (n=7) versus age-matched non-treated healthy control subjects (n=7). Psilocybin was administered in two oral dosing sessions (10 mg and 25 mg) 1 week apart. Main outcome measures were collected 1 week and 7–12 months after the second dosing session. Nature relatedness and libertarian–authoritarian political perspective were assessed using the Nature Relatedness Scale (NR-6) and Political Perspective Questionnaire (PPQ-5), respectively.

Results:
Nature relatedness significantly increased (t(6)=−4.242, p=0.003) and authoritarianism significantly decreased (t(6)=2.120, p=0.039) for the patients 1 week after the dosing sessions. At 7–12 months post-dosing, nature relatedness remained significantly increased (t(5)=−2.707, p=0.021) and authoritarianism remained decreased at trend level (t(5)=−1.811, p=0.065). No differences were found on either measure for the non-treated healthy control subjects.

Conclusions:
This pilot study suggests that psilocybin with psychological support might produce lasting changes in attitudes and beliefs. Although it would be premature to infer causality from this small study, the possibility of drug-induced changes in belief systems seems sufficiently intriguing and timely to deserve further investigation.

Eine angewiderte Dame mit einem Dinkelcroissant wirft einen Euro in den Hut und kommt sich deswegen nicht so sinnlos vor,
Im Grunde ein gutes Geschäft für sie, normalerweise muss sie für dieses Gefühl 18 Jahre lang ein Kind großziehen
Traumländer



dabei seit 2013
1.067 Forenbeiträge
2 Tripberichte

  Geschrieben: 21.03.19 10:48
Die EMCDDA (European Monitoring Centre for Drugs and Drug Addiction) hat ihren neuesten Bericht zur Abwassernanalyse von Drogenrückständen erstellt.

Hier könnt ihr Ergebnisse von 70 verschiedenen Städten Europas bei 4 populären Substanzen (Kokain, Amphetamine, Metamphetamin, MDMA) interaktiv vergleichen (ihr müsst nur auf 2. interactive klicken). Die Amphetamine-Hauptstadt von den 70 getesten Städten ist dieses Jahr überraschender Weise Saarbrücken gewesen, das hat mich doch sehr überrascht. Weniger überraschend aber dennoch interessant & wichtig: Beim Methamphetamin-Konsum landen auf den Plätzen 1-3 nur deutsche Städte (Erfurt, Chemnitz, Dresden). Beim Kokain liegt wie erwartet ne Stadt in UK und beim MDMA wie erwartet die Niederlande vorne.

Wenn ihr zusammengefasst etwas über die Methodik der Abwasseranalyse und über die wichtigsten neuen Ergebnisse etwas lesen wollt, dann könnt ihr euch diese PDF mal anschauen.

Klickt mal nen bisschen rum, ist wirklich ganz interessant. Habe selbst Leute getroffen die an solchen Abwasseranalysen zum Rückschluss auf Drogenkonsumdaten forschen, ist wirklich ne eigene kleine Wissenschaft für sich.

LG
Inc
„Ich bin nicht glücklich weils vorbei ist, es ist vorbei weil ich jetzt glücklich bin“
Degenhardt

"Mit Ehrlichkeit kommt man nicht weit, doch ohne Ehrlichkeit kommt man nicht nah"
Maeckes

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