1. its only recently that i found out that naloxone is a reverse agonist, rather than antagonist. a reverse agonist works the exact opposite of an agonist, so physiological adaptations to consistent use should hypothetically also be opposite of full agonists. an antagonist would have no such effects, as it merely blocks the receptors from being activated. this idea has facinated the hell out of me lately, because its quite possible that all of the changes brought about my opioid dependency could be completely reversed, possibly to the point where you could be back to your pre-dependency state, or hell, it might be interesting to see what might occur once a person has developed a "dependency" from using naloxone for years...

Now the placebo effect is thought to be mediated by endorphins as placebo analgesia can be blocked with intravenous naloxone and it could be that my action of giving her the naltrexone resulted in increased endorphin release and the ULDNTX potentiated these endorphin effects. She continued to use the naltrexone with good results until she finally had surgery for her spinal stenosis and thereafter needed no further exogenous analgesics.